Adverse Cutaneous Drug Reactions to Cardiovascular Drugs by Esen Özkaya & Kurtuluş Didem Yazganoğlu

Author:Esen Özkaya & Kurtuluş Didem Yazganoğlu
Language: eng
Format: epub
Publisher: Springer London, London

Lichen Planus/Lichenoid Eruption

This kind of eruption has been reported to occur with amlodipine [64, 65], nifedipine [66], and verapamil [3].

Widespread cutaneous lichenoid eruption and Wickham’s striae in the oral cavity were described in a patient, 2 weeks after starting treatment with amlodipine [64]. This patient had a history of non-insulin-dependent diabetes mellitus and was suggested as a case of Grinspan’s syndrome representing the triad of oral lichen planus, hypertension, and diabetes mellitus. Lesions improved with oral acitretin 30 mg daily for 5 weeks and additional potent topical corticosteroids, leaving residual hyperpigmentation. In another case of amlodipine-induced lichenoid eruption, the presence of transepidermal elimination of collagen with perforation in the histopathology suggested a perforating lichenoid reaction [65].

A patient under nifedipine therapy developed an erysipelas-like erythematous pruritic plaque on both shins which histopathologically showed a lichen planus-like eruption [66].

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